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SDC4

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Full Name

Syndecan 4

Function

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

Biological Process

Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inner ear receptor cell stereocilium organizationIEA:Ensembl
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of focal adhesion assemblyIEA:Ensembl
Biological Process positive regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process regulation of fibroblast migrationIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl

Cellular Location

Isoform 1
Membrane
Secreted
Shedding of the ectodomain produces a soluble form.
Isoform 2
Secreted

Topology

Extracellular: 19-145
Helical: 146-170
Cytoplasmic: 171-198

PTM

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

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Anti-SDC4 antibodies

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Mouse Recombinant SDC4 protein, His Tag (V2LY-0526-LY8946)

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Target: SDC4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-146

Tag: His Tag

Mouse Recombinant SDC4 protein, hFc Tag (V2LY-0526-LY8945)

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Target: SDC4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-146

Tag: hFc Tag

Human Recombinant SDC4 protein, His Tag (V2LY-0526-LY7037)

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Target: SDC4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-145

Tag: His Tag

SDC4 Matched Antibody Pair (1046) (APMAB-1046LY)

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Target: SDC4

Specificity: Human

Recombinant Mouse Anti-SDC4 Recombinant Antibody (V60P2C2) (CBMAB-XB1030-YC)

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Target: SDC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V60P2C2

Application*: E, IH, WB

Rat Anti-SDC4 Recombinant Antibody (CBXS-1782) (CBMAB-S4599-CQ)

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Target: SDC4

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1782

Application*: F

Rabbit Anti-SDC4 Recombinant Antibody (CBXS-1131) (CBMAB-S4015-CQ)

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Target: SDC4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-1131

Application*: P, IF, IF

Rabbit Anti-SDC4 Recombinant Antibody (CBXS-1068) (CBMAB-S3959-CQ)

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Target: SDC4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-1068

Application*: E

Mouse Anti-SDC4 Recombinant Antibody (CBXS-0165) (CBMAB-S3152-CQ)

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Target: SDC4

Host: Mouse

Specificity: Rat

Clone: CBXS-0165

Application*: WB, IC, P, C, E

Mouse Anti-SDC4 Recombinant Antibody (CBXS-0164) (CBMAB-S3151-CQ)

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Target: SDC4

Host: Mouse

Specificity: Human

Clone: CBXS-0164

Application*: WB, IC, P, C, E

Rabbit Anti-SDC4 Recombinant Antibody (CBXS-5270) (CBMAB-S2484-CQ)

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Target: SDC4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-5270

Application*: E

Mouse Anti-SDC4 Recombinant Antibody (CBXS-5190) (CBMAB-S2407-CQ)

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Target: SDC4

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-5190

Application*: WB, IP, IF, F

Rabbit Anti-SDC4 Recombinant Antibody (CBXS-3639) (CBMAB-S0920-CQ)

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Target: SDC4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-3639

Application*: WB, IP

Human Anti-SDC4 Recombinant Antibody (CBXS-3568) (CBMAB-S0390-CQ)

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Target: SDC4

Host: Human

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXS-3568

Application*: F

Mouse Anti-SDC4 Recombinant Antibody (V60P2C2/F2) (CBMAB-S0191-CQ)

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Target: SDC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V60P2C2/F2

Application*: WB, E, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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