SDC4

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Syndecan 4

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inner ear receptor cell stereocilium organizationIEA:Ensembl
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of focal adhesion assemblyIEA:Ensembl
Biological Process positive regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process regulation of fibroblast migrationIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl

Isoform 1
Membrane
Secreted
Shedding of the ectodomain produces a soluble form.
Isoform 2
Secreted

Extracellular: 19-145
Helical: 146-170
Cytoplasmic: 171-198

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.