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Rabbit Anti-SDC4 Recombinant Antibody (CBXS-3639) (CBMAB-S0920-CQ)

This product is a rabbit antibody that recognizes SDC4. The antibody CBXS-3639 can be used for immunoassay techniques such as: WB, IP.
See all SDC4 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBXS-3639
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Recombinant Mouse Syndecan-4/SDC4 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Syndecan 4
Introduction
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
Entrez Gene ID
20971
UniProt ID
O35988
Alternative Names
AA959608; AW108331; S4; Synd4; ryudocan; syndecan-4
Function
Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Biological Process
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inner ear receptor cell stereocilium organizationIEA:Ensembl
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of focal adhesion assemblyIEA:Ensembl
Biological Process positive regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process regulation of fibroblast migrationIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl
Cellular Location
Isoform 1
Membrane
Secreted
Shedding of the ectodomain produces a soluble form.
Isoform 2
Secreted
Topology
Extracellular: 19-145
Helical: 146-170
Cytoplasmic: 171-198
PTM
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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