Rat Anti-SDC4 Recombinant Antibody (CBXS-1782) (CBMAB-S4599-CQ)

Name: Rat Anti-SDC4 Recombinant Antibody (CBXS-1782)
SKU: CBMAB-S4599-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBXS-1782

Application

Immunogen

NS0-derived recombinant human Syndecan-4, Ser20-Glu145, Accession # P31431

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

A saline solution, BSA

Preservative

Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Syndecan 4

Introduction

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.

Entrez Gene ID

6385

UniProt ID

P31431

Alternative Names

Syndecan 4; Syndecan 4 (Amphiglycan, Ryudocan); Syndecan Proteoglycan 4; Ryudocan Core Protein; Amphiglycan; SYND4; Ryudocan Amphiglycan; Syndecan-4;

Function

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

Biological Process

Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inner ear receptor cell stereocilium organizationIEA:Ensembl
Biological Process negative regulation of T cell proliferationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of focal adhesion assemblyIEA:Ensembl
Biological Process positive regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process regulation of fibroblast migrationIEA:Ensembl
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl

Cellular Location

Isoform 1
Membrane
Secreted
Shedding of the ectodomain produces a soluble form.
Isoform 2
Secreted

Topology

Extracellular: 19-145
Helical: 146-170
Cytoplasmic: 171-198

PTM

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SDC4 Matched Antibody Pair (1046) (CAT#: APMAB-1046LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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