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SELE

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Full Name
Selectin E
Function
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Biological Process
Biological Process actin filament-based processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process activation of phospholipase C activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process leukocyte migration involved in inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of leukocyte tethering or rollingISS:UniProtKB
Biological Process positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to cytokineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to interleukin-1Manual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to tumor necrosis factorManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 22-556
Helical: 557-578
Cytoplasmic: 579-610

Anti-SELE antibodies

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Target: SELE
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-4420
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBWJC-4419
Application*: E, FN, C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4417
Application*: E, C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-S3
Application*: E
Target: SELE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJC-4416
Application*: F, P
Target: SELE
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4415
Application*: IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJC-4414
Application*: IH, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2394
Application*: E, F, FN, C
Target: SELE
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: UZ6
Application*: E, F, C, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: hCD62E
Application*: F
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYE-0225
Application*: WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0132
Application*: WB, IH, IP, IC, EC
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HAE-1f
Application*: F, FN
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3584
Application*: E, F, IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1861
Application*: ED
Target: SELE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1476
Application*: IH
Target: SELE
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-1603
Application*: E, F, IH, IP, WB
Target: SELE
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0786
Application*: F
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-3096
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3094
Application*: F
Target: SELE
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYC-0200
Application*: F, C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBFYC-0135
Application*: E, F, C, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYE-1641
Application*: E, WB
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1640
Application*: E, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1639
Application*: F
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1638
Application*: IF
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYE-1636
Application*: E, ED
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: CBFYE-1635
Application*: E
Target: SELE
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1634
Application*: WB, F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Baboon, Chimpanzee, Monkey, Human
Clone: CBFYE-1633
Application*: F, E, IF
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYE-1632
Application*: WB, C, IF, IP
Target: SELE
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-1630
Application*: WB, EC
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: 2Q784
Application*: E, FC, IH, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L227
Application*: IH, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K272
Application*: FC
Target: SELE
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: UZ5
Application*: E, WB, P, IP, F
Target: SELE
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: UZ4
Application*: F, IF, IP, WB
Target: SELE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0034-9J12
Application*: F, IH, P
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P2H3
Application*: F, IH, IP, P, F
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CL2/6
Application*: F, IH, IF, C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.2B6
Application*: E, F, C, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Baboon, Chimpanzee, Monkey
Clone: CBHb406
Application*: IHC-F, FuncS, Immuno assays, IF
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Baboon, Chimpanzee, Monkey
Clone: CBHb405
Application*: IHC-F, FuncS, Immuno assays, IP
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: UZ7
Application*: WB, IP, E, C, F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C2110
Application*: F
Target: SELE
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C2111
Application*: E, F, IH, IP, WB
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C2112
Application*: E, F, IH, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2113
Application*: E, F, IC, IH
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1637
Application*: E, F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2114
Application*: F, IC, IH, IP, WB
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2115
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2116
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-C2117
Application*: IH, IP
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6A512
Application*: IF, IH
Target: SELE
Host: Rabbit
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: 4A22
Application*: FC, IF, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F50
Application*: FC, IF
Target: SELE
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 4A24
Application*: E, F, IH, IP, WB
Target: SELE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 4A25
Application*: E, F, IH, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5J85
Application*: E, F, IC, IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 68-5H11
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6A510
Application*: IH, IP
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D40
Application*: E, F, IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Monkey
Clone: CBYY-C0135
Application*: F, IH, IP
Target: SELE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 414
Application*: F, IF
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4AE56
Application*: IF, F
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0545
Application*: E, F, IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0640
Application*: F
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2118
Application*: F, IH
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H1606
Application*: FC, IH
Target: SELE
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 10E9.6
Application*: F, C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-2B6
Application*: E, F, C, IP, WB
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 16G4
Application*: P
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q780
Application*: E, F, IC, IH, IP
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ENA2
Application*: C
Target: SELE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ENA1
Application*: FN, C, IP
Target: SELE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5320
Application*: F, C
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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