Rabbit Anti-SELE Recombinant Antibody (CBFYC-3096) (CBMAB-C3173-FY)

Name: Rabbit Anti-SELE Recombinant Antibody (CBFYC-3096)
SKU: CBMAB-C3173-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYC-3096

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Selectin E

Introduction

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin-and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

Entrez Gene ID

6401

UniProt ID

P16581

Alternative Names

ELAM; ESEL; CD62E; ELAM1; LECAM2

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

Biological Process

Biological Process actin filament-based processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process activation of phospholipase C activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process leukocyte migration involved in inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of leukocyte tethering or rollingISS:UniProtKB
Biological Process positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to cytokineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to interleukin-1Manual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to tumor necrosis factorManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 22-556
Helical: 557-578
Cytoplasmic: 579-610

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SELE Matched Antibody Pair (1048) (CAT#: APMAB-1048LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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