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Mouse Anti-SELE Recombinant Antibody (1-2B6) (CBMAB-C2619-LY)

This product is antibody recognizes SELE. The antibody 1-2B6 immunoassay techniques such as: ELISA, FC, IHC-F, IP, WB.
See all SELE antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1-2B6
Antibody Isotype
IgG1
Application
ELISA, FC, IHC-F, IP, WB

Basic Information

Immunogen
Human E-Selectin (ELAM-1).ImmunogenType: Purified protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Selectin E
Introduction
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Selectin E; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E; Endothelial Adhesion Molecule 1; ELAM-1; LECAM2; ELAM1; Leukocyte Endothelial Cell Adhesion Molecule 2;
Function
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Biological Process
Biological Process actin filament-based processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process activation of phospholipase C activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process leukocyte migration involved in inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of leukocyte tethering or rollingISS:UniProtKB
Biological Process positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to cytokineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to interleukin-1Manual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to tumor necrosis factorManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 22-556
Helical: 557-578
Cytoplasmic: 579-610
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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