SERPINA6

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Full Name

Serpin Family A Member 6

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Biological Process

Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Involvement in disease

Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.

PTM

N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.

Anti-SERPINA6 antibodies

Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-3714) (CBMAB-S0989-CQ)

Datasheet

SDS

Target: SERPINA6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-3714

Application*: E

Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-4713) (CBMAB-S1944-CQ)

Datasheet

SDS

Target: SERPINA6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-4713

Application*: E

Mouse Anti-SERPINA6 Recombinant Antibody (CBXS-4763) (CBMAB-S1991-CQ)

Datasheet

SDS

Target: SERPINA6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4763

Application*: E, WB

Rat Anti-SERPINA6 Recombinant Antibody (CBXS-1826) (CBMAB-S4632-CQ)

Datasheet

SDS

Target: SERPINA6

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXS-1826

Application*: WB

Mouse Anti-SERPINA6 Recombinant Antibody (CBXS-1984) (CBMAB-S4753-CQ)

Datasheet

SDS

Target: SERPINA6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBXS-1984

Application*: WB, IH

Datasheet

SDS

Target: SERPINA6

Specificity: Human

SERPINA6 Matched Antibody Pair (1065) (APMAB-1065LY)

Datasheet

SDS

Target: SERPINA6

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)