SERPINA6

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Full Name
Serpin Family A Member 6
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Biological Process
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
PTM
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
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Anti-SERPINA6 antibodies

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Mouse Anti-SERPINA6 Recombinant Antibody (CAP337) (CBMAB-AP836LY)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP337
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (CAP336) (CBMAB-AP835LY)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP336
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (1F11) (CBMAB-A7992-LY)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F11
Application*: WB, E
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (1D9) (CBMAB-A7991-LY)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9
Application*: WB, E
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (CBXS-3033) (CBMAB-S5779-CQ)

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Target: SERPINA6
Host: Mouse
Specificity: Human
Clone: CBXS-3033
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (CBXS-1984) (CBMAB-S4753-CQ)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-1984
Application*: WB, IH
Datasheet SDS

Rat Anti-SERPINA6 Recombinant Antibody (CBXS-1826) (CBMAB-S4632-CQ)

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Target: SERPINA6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1826
Application*: WB
Datasheet SDS

Mouse Anti-SERPINA6 Recombinant Antibody (CBXS-4763) (CBMAB-S1991-CQ)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4763
Application*: E, WB
Datasheet SDS

Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-4713) (CBMAB-S1944-CQ)

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Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4713
Application*: E
Datasheet SDS

Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-3714) (CBMAB-S0989-CQ)

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Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3714
Application*: E
Datasheet SDS

Mouse Anti-SERPINA6 Antibody (11BA23) (CBMAB-1554CQ)

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11BA23
Application*: E, WB
Datasheet SDS

SERPINA6 Matched Antibody Pair (1065) (APMAB-1065LY)

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Target: SERPINA6
Specificity: Human
Datasheet SDS

SERPINA6 Matched Antibody Pair (1064) (APMAB-1064LY)

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Target: SERPINA6
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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