SERPINA6
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Full Name
Serpin Family A Member 6
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Biological Process
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
PTM
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
Glycosylation in position Asn-260 is needed for steroid binding.
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Anti-SERPINA6 antibodies
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CompareTarget: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP337
Application*: ICC, IHC, IP, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP336
Application*: ICC, IHC, IP, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F11
Application*: WB, E
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9
Application*: WB, E
Target: SERPINA6
Host: Mouse
Specificity: Human
Clone: CBXS-3033
Application*: E, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-1984
Application*: WB, IH
Target: SERPINA6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1826
Application*: WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4763
Application*: E, WB
Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4713
Application*: E
Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3714
Application*: E
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11BA23
Application*: E, WB
Target: SERPINA6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-397
Tag: His Tag
Target: SERPINA6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-397
Tag: His & AVI Tag
Target: SERPINA6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-405
Tag: His Tag
Target: SERPINA6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-405
Tag: His & AVI Tag
Target: SERPINA6
Specificity: Human
Target: SERPINA6
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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