Rat Anti-SERPINA6 Recombinant Antibody (CBXS-1826) (CBMAB-S4632-CQ)

Name: Rat Anti-SERPINA6 Recombinant Antibody (CBXS-1826)
SKU: CBMAB-S4632-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBXS-1826

Application

Immunogen

NS0-derived recombinant mouse Serpin A6, Val23-Ala397, Accession # Q06770

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serpin Family A Member 6

Introduction

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Entrez Gene ID

12401

UniProt ID

Q06770

Alternative Names

Cbg

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Biological Process

Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Involvement in disease

Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.

PTM

N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SERPINA6 Matched Antibody Pair (1064) (CAT#: APMAB-1064LY)

SERPINA6 Matched Antibody Pair (1065) (CAT#: APMAB-1065LY)

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Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-4713) (CAT#: CBMAB-S1944-CQ)

Rabbit Anti-SERPINA6 Recombinant Antibody (CBXS-3714) (CAT#: CBMAB-S0989-CQ)

SERPINA6 Matched Antibody Pair (1065) (CAT#: APMAB-1065LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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