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Mouse Anti-SERPINA6 Recombinant Antibody (CAP337) (CBMAB-AP836LY)


See all SERPINA6 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CAP337
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Lys173~Leu344
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Serpin Family A Member 6
Introduction
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Entrez Gene ID
299270
UniProt ID
P31211
Alternative Names
Serpin Family A Member 6; Transcortin; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6; Serpin A6; CBG; Corticosteroid Binding Globulin; Corticosteroid-Binding Globulin;
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Biological Process
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
PTM
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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