SHC4

SHC4 (SHC Adaptor Protein 4) is a protein coding gene. Diseases associated with SHC4 include Male Reproductive Organ Cancer. Among its related pathways are Endometrial cancer and MicroRNAs in cancer. Gene Ontology annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
Full Name
SHC4
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Biological Process
Biological Process apoptotic processIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl
Biological Process stem cell differentiationIEA:Ensembl
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Postsynaptic cell membrane
Colocalized with MUSK at the neuromuscular junction.
PTM
Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
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Anti-SHC4 antibodies

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Mouse Anti-SHC4 Recombinant Antibody (2F5) (CBMAB-A8110-LY)

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Target: SHC4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2F5
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-SHC4 Recombinant Antibody (AI22-20) (CBMAB-XB1033-YC)

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Target: SHC4
Host: Mouse
Specificity: Human, Mouse
Clone: AI22-20
Application*: IH, IF, WB
Datasheet SDS

Mouse Anti-SHC4 Recombinant Antibody (15G6) (CBMAB-0921-CN)

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Target: SHC4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15G6
Application*: E, M
Datasheet SDS

Mouse Anti-SHC4 Recombinant Antibody (CBXS-0354) (CBMAB-S3325-CQ)

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Target: SHC4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0354
Application*: WB, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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