SIN3B

SIN3B is a protein-coding gene, which is a specific and essential actor in promoting cell cycle exit via the E2F-Rb pathway. Diseases associated with SIN3B include cranial nerve malignant neoplasm and olfactory nerve neoplasm. Among its related pathways are SMAD signaling network and metabolism. Go annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity.
Full Name
SIN3B
Function
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
Biological Process
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by RNF220 that leads to proteasomal degradation.
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Anti-SIN3B antibodies

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Mouse Anti-SIN3B Monoclonal Antibody (1A9) (CBMAB-0100-LY)

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Target: SIN3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: IP, E
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Mouse Anti-SIN3B Recombinant Antibody (2C11) (CBMAB-A8132-LY)

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Target: SIN3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C11
Application*: SE, E
Datasheet SDS

Mouse Anti-SIN3B Recombinant Antibody (CBXS-4427) (CBMAB-S1669-CQ)

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Target: SIN3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4427
Application*: E
Datasheet SDS

Mouse Anti-SIN3B Recombinant Antibody (CBFYM-3122) (CBMAB-M3319-FY)

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Target: SIN3B
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYM-3122
Application*: WB, IP, IF, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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