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Mouse Anti-SIN3B Recombinant Antibody (2C11) (CBMAB-A8132-LY)

The product is antibody recognizes SIN3B. The antibody 2C11 immunoassay techniques such as: sELISA, ELISA.
See all SIN3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C11
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SIN3B (NP_056075.1, 1063 a.a. ~ 1160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SIN3B
Entrez Gene ID
23309
UniProt ID
O75182
Alternative Names
KIAA0700
Function
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
Biological Process
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by RNF220 that leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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