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Mouse Anti-SIN3B Recombinant Antibody (CBFYM-3122) (CBMAB-M3319-FY)

This product is mouse antibody that recognizes SIN3B. The antibody CBFYM-3122 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SIN3B antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-3122
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SIN3B
Introduction
Genetic inactivation of Sin3B represents a unique opportunity to dissect the physiological relevance of cellular senescence in pancreatic cancer progression.
Entrez Gene ID
Human23309
Mouse20467
Rat683381
UniProt ID
HumanO75182
MouseQ62141
RatB0BNJ0
Alternative Names
SIN3 Transcription Regulator Family Member B; SIN3 Homolog B, Transcription Regulator (Yeast); SIN3 Transcription Regulator Homolog B (Yeast); Histone Deacetylase Complex Subunit Sin3b; Transcriptional Corepressor Sin3b; KIAA0700
Function
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
Biological Process
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated by RNF220 that leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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