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SIRPA

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Full Name
signal regulatory protein alpha
Function
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).
Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell migrationISS:ARUK-UCL
Biological Process cellular response to hydrogen peroxideISS:ARUK-UCL
Biological Process cellular response to interferon-gammaISS:ARUK-UCL
Biological Process cellular response to interleukin-1ISS:ARUK-UCL
Biological Process cellular response to interleukin-12Manual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process cellular response to lipopolysaccharideISS:ARUK-UCL
Biological Process monocyte extravasationISS:ARUK-UCL
Biological Process negative regulation of chemokine (C-C motif) ligand 5 productionISS:ARUK-UCL
Biological Process negative regulation of cytokine production involved in inflammatory responseISS:ARUK-UCL
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:ARUK-UCL
Biological Process negative regulation of I-kappaB phosphorylationISS:ARUK-UCL
Biological Process negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of interferon-beta productionISS:ARUK-UCL
Biological Process negative regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process negative regulation of JNK cascadeISS:ARUK-UCL
Biological Process negative regulation of macrophage inflammatory protein 1 alpha productionISS:ARUK-UCL
Biological Process negative regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process negative regulation of phagocytosisISS:ARUK-UCL
Biological Process negative regulation of protein phosphorylationISS:ARUK-UCL
Biological Process negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interleukin-1 beta productionISS:ARUK-UCL
Biological Process regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Cellular Location
Membrane
Topology
Extracellular: 31-373
Helical: 374-394
Cytoplasmic: 395-504
PTM
N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.

Anti-SIRPA antibodies

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Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0302
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: BA0421
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: ED9
Application*: F, C, IP, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-3114
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human
Clone: CBFYC-3115
Application*: WB
Target: SIRPA
Host: Mouse
Specificity: Rat
Clone: OX41
Application*: WB, IP, IF, P, F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBXS-3184
Application*: E, IF, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-3129
Application*: F, IH, WB
Target: SIRPA
Host: Mouse
Specificity: Human
Clone: CBXS-2730
Application*: E, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-2324
Application*: F, IH, IP, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-2323
Application*: F, IH
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-2322
Application*: F
Target: SIRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1416
Application*: WB, F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-0379
Application*: F, C, P
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-0378
Application*: F, C, P, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: CBXS-0377
Application*: F, IF
Target: SIRPA
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5420
Application*: WB, P, IF
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5247
Application*: WB, IH
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4199
Application*: WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3878
Application*: WB
Target: SIRPA
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBXS-3705
Application*: IC, IH, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1115
Application*: WB, E, F
Target: SIRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1051
Application*: E, F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: OX-41
Application*: WB, F, IH, P, C
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBXS-1935
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1866
Application*: F
Target: SIRPA
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0717
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: CC149
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: BL1H7
Application*: F
Target: SIRPA
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: P84
Application*: F, IF
Target: SIRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR049F
Application*: WB, IP, IHC, ICC
Target: SIRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D6I3M
Application*: WB, P, IF (IC), F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: P3C4
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SE5A5
Application*: F
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: CBYY-C2127
Application*: IF, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 4C7
Application*: IF, WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 1D10
Application*: WB
Target: SIRPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 15-414
Application*: F, C
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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