Mouse Sirpa ELISA Kit (V2LY-0626-LY3184)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0098 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
56.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
signal regulatory protein alpha
Alternative Names
Signal Regulatory Protein Alpha; CD172 Antigen-Like Family Member A; Inhibitory Receptor SHPS-1; Macrophage Fusion Receptor; PTPNS1; SHPS1; SIRP; P84; BIT; MFR; Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs; Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs; Protein Tyrosine Phosphatase; Non-Receptor Type Substrate 1; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; Tyrosine Phosphatase SHP Substrate 1; Signal-Regulatory Protein Alpha-1;
Function
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).
Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell migrationISS:ARUK-UCL
Biological Process cellular response to hydrogen peroxideISS:ARUK-UCL
Biological Process cellular response to interferon-gammaISS:ARUK-UCL
Biological Process cellular response to interleukin-1ISS:ARUK-UCL
Biological Process cellular response to interleukin-12Manual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process cellular response to lipopolysaccharideISS:ARUK-UCL
Biological Process monocyte extravasationISS:ARUK-UCL
Biological Process negative regulation of chemokine (C-C motif) ligand 5 productionISS:ARUK-UCL
Biological Process negative regulation of cytokine production involved in inflammatory responseISS:ARUK-UCL
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:ARUK-UCL
Biological Process negative regulation of I-kappaB phosphorylationISS:ARUK-UCL
Biological Process negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of interferon-beta productionISS:ARUK-UCL
Biological Process negative regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process negative regulation of JNK cascadeISS:ARUK-UCL
Biological Process negative regulation of macrophage inflammatory protein 1 alpha productionISS:ARUK-UCL
Biological Process negative regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process negative regulation of phagocytosisISS:ARUK-UCL
Biological Process negative regulation of protein phosphorylationISS:ARUK-UCL
Biological Process negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of interleukin-1 beta productionISS:ARUK-UCL
Biological Process regulation of interleukin-6 productionISS:ARUK-UCL
Biological Process regulation of nitric oxide biosynthetic processISS:ARUK-UCL
Biological Process regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Cellular Location
Membrane
Topology
Extracellular: 31-373
Helical: 374-394
Cytoplasmic: 395-504
PTM
N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant SIRPA protein, His Tag (CAT#: V2LY-0526-LY1640)

Human Recombinant SIRPA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY6815)

Human Recombinant SIRPA protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY6816)

Human Recombinant SIRPA protein, ECD, His Tag (CAT#: V2LY-0526-LY6817)

Human Recombinant SIRPA (SIRP alphaV2) protein, ECD, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY6818)

Human Recombinant SIRPA (SIRP alphaV2) protein, ECD, His Tag (CAT#: V2LY-0526-LY6819)

Human Recombinant SIRPA (SIRP alphaV2) protein, ECD, Fc Tag (CAT#: V2LY-0526-LY6820)

Human Recombinant SIRPA (SIRP alphaV8) protein, ECD, His Tag (CAT#: V2LY-0526-LY6821)

Human Recombinant SIRPA (SIRP alphaV8) protein, ECD, Fc Tag (CAT#: V2LY-0526-LY6822)

Human Recombinant SIRPA (G75A) protein, ECD, His Tag (CAT#: V2LY-0526-LY6823)

Related Products

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Rat Anti-SIRPA Recombinant Antibody (CBXS-3705) (CAT#: CBMAB-S0980-CQ)

Mouse Anti-SIRPA Recombinant Antibody (CBT3992) (CAT#: V2LY-0625-LY865)

Mouse Recombinant SIRPA protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY8911)

Rabbit Anti-SIRPA Recombinant Antibody (D6I3M) (CAT#: CBMAB-CP2433-LY)

Mouse Anti-SIRPA Recombinant Antibody (CBXS-3184) (CAT#: CBMAB-S5926-CQ)

Mouse Anti-SIRPA (AA 28-508) Recombinant Antibody (CBFYC-3115) (CAT#: CBMAB-C3192-FY)

Mouse Anti-SIRPA Recombinant Antibody (CBXS-3878) (CAT#: CBMAB-S1147-CQ)

Rabbit Anti-SIRPA Recombinant Antibody (CBXS-5420) (CAT#: CBMAB-S2631-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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