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SLC27A5

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq]
Full Name
solute carrier family 27 (fatty acid transporter), member 5
Function
May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735).
Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480).
Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911).
Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911).
In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911).
Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
Biological Process
Biological Process bile acid and bile salt transportTAS:Reactome
Biological Process bile acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process ketone body biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process triglyceride mobilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process very long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Microsome
Cell membrane
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Anti-SLC27A5 antibodies

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Mouse Anti-SLC27A5 Recombinant Antibody (5A7) (CBMAB-A8211-LY)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A7
Application*: WB, E
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXS-2532) (CBMAB-S5288-CQ)

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Target: SLC27A5
Host: Mouse
Specificity: Human, Monkey, Mouse
Clone: CBXS-2532
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXS-2531) (CBMAB-S5287-CQ)

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Target: SLC27A5
Host: Mouse
Specificity: Human, Mouse
Clone: CBXS-2531
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXS-2530) (CBMAB-S5286-CQ)

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Target: SLC27A5
Host: Mouse
Specificity: Human, Monkey, Mouse
Clone: CBXS-2530
Application*: E, F, IH, WB
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (9C4D1) (CBMAB-S2901-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 9C4D1
Application*: E, IH, P, WB
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (4B11C10) (CBMAB-S2852-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 4B11C10
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXS-5301) (CBMAB-S2515-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5301
Application*: WB, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXS-4721) (CBMAB-S1951-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4721
Application*: F
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2485) (CBMAB-F2014-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2485
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2484) (CBMAB-F2013-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2484
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2483) (CBMAB-F2012-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2483
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2482) (CBMAB-F1888-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-2482
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2481) (CBMAB-F1377-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-2481
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBXF-2707) (CBMAB-F0153-CQ)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2707
Application*: F
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBT2295) (V2LY-0625-LY945)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT2295
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBT4167) (V2LY-0625-LY944)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4167
Application*: IH
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBT3410) (V2LY-0625-LY943)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT3410
Application*: IH
Datasheet SDS

Mouse Anti-SLC27A5 Recombinant Antibody (CBT4597) (V2LY-0625-LY942)

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Target: SLC27A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4597
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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