Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLC27A5 Recombinant Antibody (5A7) (CBMAB-A8211-LY)

The product is antibody recognizes SLC27A5. The antibody 5A7 immunoassay techniques such as: WB, ELISA.
See all SLC27A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5A7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC27A5 (NP_036386, 90 a.a. ~ 175 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 27 (fatty acid transporter), member 5
Introduction
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq]
Entrez Gene ID
10998
UniProt ID
Q9Y2P5
Alternative Names
ACSB; ACSVL6; FACVL3; FATP5; FLJ22987; VLACSR; VLCS-H2; VLCSH2
Function
May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735).
Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480).
Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911).
Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911).
In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911).
Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
Biological Process
Biological Process bile acid and bile salt transportTAS:Reactome
Biological Process bile acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process ketone body biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process triglyceride mobilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process very long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Microsome
Cell membrane
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLC27A5 Recombinant Antibody (5A7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare