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Mouse Anti-SLC27A5 Recombinant Antibody (4B11C10) (CBMAB-S2852-CQ)

This product is a mouse antibody that recognizes SLC27A5. The antibody 4B11C10 can be used for immunoassay techniques such as: FC, IHC, WB.
See all SLC27A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4B11C10
Antibody Isotype
IgG1
Application
FC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human SLC27A5 (aa 508-570)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% proprietary stabilizer
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 27 (fatty acid transporter), member 5
Introduction
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.
Entrez Gene ID
Human10998
Mouse26459
UniProt ID
HumanQ9Y2P5
MouseQ4LDG0
Alternative Names
Solute Carrier Family 27 Member 5; Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 3; Solute Carrier Family 27 (Fatty Acid Transporter), Member 5; Very Long-Chain Acyl-CoA Synthetase-Related Protein; Very Long-Chain Acyl-CoA Synthetase Homolog 2; Fatty Acid Transport Protein 5; Bile Acid-CoA Ligase; Cholate--CoA Ligase; BA-CoA Ligase; VLACS-Related; VLCS-H2; ACSVL6;
Function
May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735).
Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480).
Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911).
Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911).
In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911).
Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
Biological Process
Biological Process bile acid and bile salt transportTAS:Reactome
Biological Process bile acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process ketone body biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process triglyceride mobilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process very long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Microsome
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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