SLC5A5

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.

solute carrier family 5 member 5

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).

Biological Process cellular response to cAMPManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to forskolinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to Thyroid stimulating hormoneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process iodide transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone generationTAS:Reactome
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cell membrane
Cytoplasm

Thyroid dyshormonogenesis 1 (TDH1):
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.

Glycosylated.