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SLC5A5

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
Full Name
solute carrier family 5 member 5
Function
Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).
Biological Process
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to forskolinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to Thyroid stimulating hormoneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process iodide transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone generationTAS:Reactome
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Cytoplasm
Involvement in disease
Thyroid dyshormonogenesis 1 (TDH1):
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
PTM
Glycosylated.
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Anti-SLC5A5 antibodies

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Mouse Anti-SLC5A5 Recombinant Antibody (SPM186) (CBMAB-S6609-CQ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM186
Application*: IF, IH, C, P, WB
Datasheet SDS

Mouse Anti-SLC5A5 (AA 468-643) Recombinant Antibody (SPM178) (CBMAB-S6608-CQ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM178
Application*: WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (CBXS-6153) (CBMAB-S6329-CQ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-6153
Application*: P, WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (CBXS-1969) (CBMAB-S0151-CQ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1969
Application*: F
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (G-5) (CBMAB-N4284-WJ)

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Target: SLC5A5
Host: Mouse
Specificity: Mouse
Clone: G-5
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (5G132) (CBMAB-N4283-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5G132
Application*: IH, WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (2Q2313) (CBMAB-N4282-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q2313
Application*: IH, WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (2Q2312) (CBMAB-N4281-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q2312
Application*: IH, WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (12F4) (CBMAB-N4280-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 12F4
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (12F3) (CBMAB-N4279-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 12F3
Application*: WB
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (FP5) (CBMAB-N0607-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: FP5
Application*: WB, P
Datasheet SDS

Mouse Anti-SLC5A5 Recombinant Antibody (14F) (CBMAB-N0606-WJ)

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Target: SLC5A5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 14F
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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