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Mouse Anti-SLC5A5 Recombinant Antibody (12F3) (CBMAB-N4279-WJ)

This product is a Mouse antibody that recognizes SLC5A5. The antibody 12F3 can be used for immunoassay techniques such as: WB.
See all SLC5A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
12F3
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 5 member 5
Introduction
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
Entrez Gene ID
Human6528
Mouse114479
Rat114613
UniProt ID
HumanQ92911
MouseQ99PN0
RatQ63008
Alternative Names
Solute Carrier Family 5 Member 5; Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 5; Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5; Na(+)/I(-) Cotransporter; Na(+)/I(-) Symporter; NIS; Sodium/Iodide Cotransporter; Sodium-Iodide Symporter; TDH1;
Function
Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).
Biological Process
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to forskolinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to Thyroid stimulating hormoneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process iodide transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone generationTAS:Reactome
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Cytoplasm
Involvement in disease
Thyroid dyshormonogenesis 1 (TDH1):
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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