Mouse Anti-SLC5A5 Recombinant Antibody (SPM186) (CBMAB-S6609-CQ)

Name: Mouse Anti-SLC5A5 Recombinant Antibody (SPM186)
SKU: CBMAB-S6609-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

SPM186

Application

IF, IHC, IHC-Fr, IHC-P, WB

Immunogen

Synthetic peptide: WTPCV GHDGGRDQQE TNL, corresponding to amino acids 625-643 of Human Sodium Iodide Symporter

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.09% sodium azide

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 5 member 5

Introduction

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.

Entrez Gene ID

6528

UniProt ID

Q92911

Alternative Names

Solute Carrier Family 5 Member 5; Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 5; Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5; Na(+)/I(-) Cotransporter; Na(+)/I(-) Symporter; NIS; Sodium/Iodide Cotransporter; Sodium-Iodide Symporter; TDH1;

Function

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).

Biological Process

Biological Process cellular response to cAMPManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to forskolinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to Thyroid stimulating hormoneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process iodide transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone generationTAS:Reactome
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Cell membrane
Cytoplasm

Involvement in disease

Thyroid dyshormonogenesis 1 (TDH1):
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.

PTM

Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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