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Mouse Anti-SLC5A5 Recombinant Antibody (CBXS-1969) (CBMAB-S0151-CQ)

This product is a mouse antibody that recognizes SLC5A5. The antibody CBXS-1969 can be used for immunoassay techniques such as: FC.
See all SLC5A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1969
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human SLC5A5, Accession # Q92911
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 5 member 5
Introduction
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
Entrez Gene ID
6528
UniProt ID
Q92911
Alternative Names
Solute Carrier Family 5 Member 5; Solute Carrier Family 5 (Sodium/Iodide Cotransporter), Member 5; Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5; Na(+)/I(-) Cotransporter; Na(+)/I(-) Symporter; NIS; Sodium/Iodide Cotransporter; Sodium-Iodide Symporter; TDH1;
Function
Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:8806637, PubMed:9329364, PubMed:20797386, PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:31310151, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).
Biological Process
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to forskolinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process cellular response to Thyroid stimulating hormoneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process iodide transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone generationTAS:Reactome
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Cytoplasm
Involvement in disease
Thyroid dyshormonogenesis 1 (TDH1):
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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