SLC9A3R2

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Full Name

SLC9A3 Regulator 2

Function

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453).
May also act as scaffold protein in the nucleus.

Biological Process

Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endomembrane system
Nucleus
Apical cell membrane
Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity).
Nuclear, in a punctate pattern.