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Mouse Anti-SLC9A3R2 Recombinant Antibody (CBXS-4692) (CBMAB-S1926-CQ)

This product is a mouse antibody that recognizes SLC9A3R2. The antibody CBXS-4692 can be used for immunoassay techniques such as: WB, IP.
See all SLC9A3R2 antibodies
Published Data
Fig.1 The asterisk denotes the band representing the total amount of immunoprecipitated NHERF2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4692
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLC9A3 Regulator 2
Introduction
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
9351
UniProt ID
Q15599
Alternative Names
SLC9A3 Regulator 2; Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3 Regulator 2; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulatory Factor 2; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulator 2; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 2; Solute Carrier Family 9 Isoform A3 Regulatory Factor 2; NHE3 Kinase A Regulatory Protein E3KARP; Tyrosine Kinase Activator Protein 1; SRY-Interacting Protein 1; NHERF-2; NHERF2;
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453).
May also act as scaffold protein in the nucleus.
Biological Process
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endomembrane system
Nucleus
Apical cell membrane
Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity).
Nuclear, in a punctate pattern.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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