SMYD2

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Full Name
SET And MYND Domain Containing 2
Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process heart developmentIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transduction by p53 class mediatorTAS:Reactome
Cellular Location
Cytoplasm, cytosol
Nucleus
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Anti-SMYD2 antibodies

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Human Recombinant SMYD2 protein, His Tag (V2LY-0526-LY6896)

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Target: SMYD2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-433
Tag: His Tag
Datasheet SDS

Human Recombinant SMYD2, Active protein, GST Tag (V2LY-0526-LY6895)

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Target: SMYD2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (CBT3550) (V2LY-0625-LY1249)

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Target: SMYD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3550
Application*: F
Datasheet SDS

SMYD2 Matched Antibody Pair (1105) (APMAB-1105LY)

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Target: SMYD2
Specificity: Human
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (CBXS-2602) (CBMAB-S5357-CQ)

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Target: SMYD2
Host: Mouse
Specificity: Human, Mouse
Clone: CBXS-2602
Application*: WB
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (CBXS-2519) (CBMAB-S5276-CQ)

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Target: SMYD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-2519
Application*: WB
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (CBXS-0585) (CBMAB-S3527-CQ)

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Target: SMYD2
Host: Mouse
Specificity: Human
Clone: CBXS-0585
Application*: WB
Datasheet SDS

Rabbit Anti-SMYD2 Recombinant Antibody (CBXS-0584) (CBMAB-S3526-CQ)

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Target: SMYD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Clone: CBXS-0584
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMYD2 Recombinant Antibody (CBXS-5337) (CBMAB-S2550-CQ)

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Target: SMYD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Clone: CBXS-5337
Application*: WB, IP
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (CBXS-4152) (CBMAB-S1405-CQ)

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Target: SMYD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-4152
Application*: WB
Datasheet SDS

Rabbit Anti-SMYD2 Recombinant Antibody (CBLY1-175) (CBMAB-K2203-LY)

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Target: SMYD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBLY1-175
Application*: WB, F, IC/IF
Datasheet SDS

Mouse Anti-SMYD2 Recombinant Antibody (14D3) (CBMAB-0929-CN)

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Target: SMYD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 14D3
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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