Human Recombinant SMYD2, Active protein, GST Tag (V2LY-0526-LY6895)

Name: Human Recombinant SMYD2, Active protein, GST Tag
SKU: V2LY-0526-LY6895
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant SMYD2, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

SET And MYND Domain Containing 2

Function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Biological Process

Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process heart developmentIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transduction by p53 class mediatorTAS:Reactome

Cellular Location

Cytoplasm, cytosol
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

SMYD2 Matched Antibody Pair (1105) (CAT#: APMAB-1105LY)

Human Recombinant SMYD2 protein, His Tag (CAT#: V2LY-0526-LY6896)

Antibody Pairs

SMYD2 Matched Antibody Pair (1105) (CAT#: APMAB-1105LY)

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Mouse Anti-SMYD2 Recombinant Antibody (CBXS-2519) (CAT#: CBMAB-S5276-CQ)

Mouse Anti-SMYD2 Recombinant Antibody (CBXS-0585) (CAT#: CBMAB-S3527-CQ)

Human Recombinant SMYD2 protein, His Tag (CAT#: V2LY-0526-LY6896)

Rabbit Anti-SMYD2 Recombinant Antibody (CBLY1-175) (CAT#: CBMAB-K2203-LY)

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SMYD2 Matched Antibody Pair (1105) (CAT#: APMAB-1105LY)

Mouse Anti-SMYD2 Recombinant Antibody (CBT3550) (CAT#: V2LY-0625-LY1249)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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