SUSD2
SUSD2 (Sushi Domain Containing 2) is a Protein Coding gene. Diseases associated with SUSD2 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is MUC4.May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).
Full Name
Sushi Domain Containing 2
Function
May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403).
May play a role in breast tumorigenesis (PubMed:23131994).
May play a role in breast tumorigenesis (PubMed:23131994).
Biological Process
Biological Process negative regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell divisionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell divisionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.
SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.
Topology
Extracellular: 28-785
Helical: 786-806
Cytoplasmic: 807-822
Helical: 786-806
Cytoplasmic: 807-822
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Anti-SUSD2 antibodies
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Target: SUSD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-3676
Application*: WB, F, MC
Target: SUSD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1990
Application*: F, MC
Target: SUSD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1989
Application*: WB, IH
Target: SUSD2
Sensitivity: 0.0099 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Susd2
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: SUSD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-1620
Application*: WB, F
Target: SUSD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5
Application*: F, IF
Target: SUSD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3677
Application*: WB, IH, F, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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