TAPBP

Tapbp is involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide.

Full Name

TAPBP

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Biological Process

Biological Process antigen processing and presentation of endogenous peptide antigen via MHC class IIEA:InterPro
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process MHC class I protein complex assemblyIBA:GO_Central1 Publication
Biological Process MHC class Ib protein complex assemblyIMP:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:ComplexPortal1 Publication
Biological Process peptide antigen stabilizationISS:UniProtKB
Biological Process protein-containing complex assemblyIDA:UniProtKB1 Publication
Biological Process regulation of gene expressionIMP:AgBase1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Biological Process regulation of protein complex stabilityIDA:AgBase1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumNAS:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Bare lymphocyte syndrome 1 (BLS1):
A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.

Topology

Lumenal: 21-414
Helical: 415-435
Cytoplasmic: 436-448