Mouse Anti-TAPBP Recombinant Antibody (CBYJT-1967) (CBMAB-T1055-YJ)

Name: Mouse Anti-TAPBP Recombinant Antibody (CBYJT-1967)
SKU: CBMAB-T1055-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1967

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TAPBP

Introduction

TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. TAPBP contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. TAPBP lies within the major histocompatibility complex on chromosome 6.

Entrez Gene ID

6892

UniProt ID

O15533

Alternative Names

TAP Binding Protein; TAP Binding Protein (Tapasin); TAP-Associated Protein; Tapasin; NGS-17; NGS17

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Biological Process

Biological Process antigen processing and presentation of endogenous peptide antigen via MHC class IIEA:InterPro
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process MHC class I protein complex assemblyIBA:GO_Central1 Publication
Biological Process MHC class Ib protein complex assemblyIMP:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:ComplexPortal1 Publication
Biological Process peptide antigen stabilizationISS:UniProtKB
Biological Process protein-containing complex assemblyIDA:UniProtKB1 Publication
Biological Process regulation of gene expressionIMP:AgBase1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Biological Process regulation of protein complex stabilityIDA:AgBase1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumNAS:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Bare lymphocyte syndrome 1 (BLS1):
A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.

Topology

Lumenal: 21-414
Helical: 415-435
Cytoplasmic: 436-448

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TAPBP Recombinant Antibody (CBYJT-1968) (CAT#: CBMAB-T1056-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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