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Hamster Anti-Tapbp Recombinant Antibody (CBYJT-1969) (CBMAB-T1057-YJ)

Provided herein is a Hamster monoclonal antibody, which binds to Tapbp (TAP Binding Protein). The antibody can be used for immunoassay techniques, such as WB.
See all Tapbp antibodies

Summary

Host Animal
Hamster
Specificity
Mouse
Clone
CBYJT-1969
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Partial mouse tapasin peptide (11-34 a.a.)
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 11-34

Target

Full Name
TAPBP
Introduction
Tapbp is involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide.
Entrez Gene ID
21356
UniProt ID
Q9R233
Alternative Names
TPN; D17Wsu91e
Function
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Biological Process
Biological Process antigen processing and presentation of endogenous peptide antigen via MHC class IIEA:InterPro
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process MHC class I protein complex assemblyIBA:GO_Central1 Publication
Biological Process MHC class Ib protein complex assemblyIMP:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:ComplexPortal1 Publication
Biological Process peptide antigen stabilizationISS:UniProtKB
Biological Process protein-containing complex assemblyIDA:UniProtKB1 Publication
Biological Process regulation of gene expressionIMP:AgBase1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Biological Process regulation of protein complex stabilityIDA:AgBase1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumNAS:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Bare lymphocyte syndrome 1 (BLS1):
A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Topology
Lumenal: 21-414
Helical: 415-435
Cytoplasmic: 436-448
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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