Human Recombinant TAPBP protein, His Tag (V2LY-0526-LY7057)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant TAPBP protein, His Tag consist of Amino Acid: 1-414 and predicts a molecular mass of 43.5 kDa.
Molecule Mass
43.5 kDa
Sequence
Amino Acid: 1-414
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TAPBP
Function
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Biological Process
Biological Process antigen processing and presentation of endogenous peptide antigen via MHC class IIEA:InterPro
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process MHC class I protein complex assemblyIBA:GO_Central1 Publication
Biological Process MHC class Ib protein complex assemblyIMP:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:ComplexPortal1 Publication
Biological Process peptide antigen stabilizationISS:UniProtKB
Biological Process protein-containing complex assemblyIDA:UniProtKB1 Publication
Biological Process regulation of gene expressionIMP:AgBase1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Biological Process regulation of protein complex stabilityIDA:AgBase1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumNAS:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Bare lymphocyte syndrome 1 (BLS1):
A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Topology
Lumenal: 21-414
Helical: 415-435
Cytoplasmic: 436-448
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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