TFAP2C

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq]
Full Name
TFAP2C
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Biological Process
Biological Process anatomical structure developmentSource:GO_Central1 Publication
Biological Process cell-cell signalingSource:ProtInc1 Publication
Biological Process male gonad developmentSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process regulation of gene expression, epigeneticSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
PTM
Sumoylated on Lys-10; which inhibits transcriptional activity.
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Anti-TFAP2C antibodies

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Mouse Anti-TFAP2C Recombinant Antibody (3C8) (CBMAB-A9030-LY)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C8
Application*: WB, E
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (CBYJT-2634) (CBMAB-T1811-YJ)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2634
Application*: WB
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (CBYJT-2633) (CBMAB-T1810-YJ)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2633
Application*: E, WB
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (AP25H01) (CBMAB-T1809-YJ)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AP25H01
Application*: DB, WB
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (CBYJT-2632) (CBMAB-T1808-YJ)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2632
Application*: E, WB
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (CBT2516) (V2LY-0625-LY712)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2516
Application*: WB, IH
Datasheet SDS

Mouse Anti-TFAP2C Recombinant Antibody (CBT2900) (V2LY-0625-LY711)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2900
Application*: WB
Datasheet SDS

Mouse Anti-TFAP2C Monoclonal Antibody (1B9) (CBMAB-0245-LY)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B9
Application*: IP, M
Datasheet SDS

Mouse Anti-TFAP2C Monoclonal Antibody (1A7) (CBMAB-0244-LY)

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Target: TFAP2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7
Application*: IP, M
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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