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TMEM230

This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017]
Full Name
Transmembrane Protein 230
Function
Involved in trafficking and recycling of synaptic vesicles.
Biological Process
Synaptic vesicle transport
Cellular Location
Membrane
Golgi apparatus, trans-Golgi network
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Early endosome
Recycling endosome
Late endosome
Cytoplasmic vesicle, autophagosome
Involvement in disease
Parkinson disease (PARK):
A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.
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Anti-TMEM230 antibodies

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Mouse Anti-TMEM230 Recombinant Antibody (CBYJT-3518) (CBMAB-T2843-YJ)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3518
Application*: F, WB
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (CBYJT-3517) (CBMAB-T2842-YJ)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3517
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (CBYJT-3516) (CBMAB-T2841-YJ)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3516
Application*: F, WB
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (3B2) (CBMAB-C5703-LY)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B2
Application*: C, WB
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (2C8) (CBMAB-C4827-LY)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 2C8
Application*: WB, F, IC/IF
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (CBWJC-4508) (CBMAB-C5901WJ)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJC-4508
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TMEM230 Recombinant Antibody (CBWJC-4507) (CBMAB-C5900WJ)

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Target: TMEM230
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4507
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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