TMOD1
This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Full Name
TMOD1 Gene(Protein Coding) Tropomodulin 1
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Biological Process
Biological Process actin filament organizationSource:GO_Central1 Publication
Biological Process adult locomotory behaviorSource:Ensembl
Biological Process lens fiber cell developmentSource:Ensembl
Biological Process muscle contractionSource:GO_Central1 Publication
Biological Process myofibril assemblySource:GO_Central1 Publication
Biological Process pointed-end actin filament cappingSource:InterPro
Biological Process adult locomotory behaviorSource:Ensembl
Biological Process lens fiber cell developmentSource:Ensembl
Biological Process muscle contractionSource:GO_Central1 Publication
Biological Process myofibril assemblySource:GO_Central1 Publication
Biological Process pointed-end actin filament cappingSource:InterPro
Cellular Location
Cytoplasm, cytoskeleton
In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
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Anti-TMOD1 antibodies
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CompareTarget: TMOD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat, Monkey, Mouse
Clone: CBYJT-3545
Application*: WB, IH, IF
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3544
Application*: WB, IF, F
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3543
Application*: WB, IF, F
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3542
Application*: WB, IF, F
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3541
Application*: F, IF, WB
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3540
Application*: WB, IF, F
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3539
Application*: WB
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3538
Application*: WB, IH, IF, F
Target: TMOD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: TRM-17 (Mab17)
Application*: E, IF, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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