Mouse Anti-TMOD1 Recombinant Antibody (CBYJT-3542) (CBMAB-T2868-YJ)

Name: Mouse Anti-TMOD1 Recombinant Antibody (CBYJT-3542)
SKU: CBMAB-T2868-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3542

Application

WB, IF, FC

Immunogen

Full length human recombinant protein of human TMOD1 (NP_003266) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TMOD1 Gene(Protein Coding) Tropomodulin 1

Introduction

TMOD1 is a member of the tropomodulin family. TMOD1 is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton.

Entrez Gene ID

7111

UniProt ID

P28289

Alternative Names

Tropomodulin 1; Erythrocyte Tropomodulin; D9S57E; E-Tmod; TMOD; E-Tropomodulin; Tropomodulin-1; ETMOD

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Biological Process

Biological Process actin filament organizationSource:GO_Central1 Publication
Biological Process adult locomotory behaviorSource:Ensembl
Biological Process lens fiber cell developmentSource:Ensembl
Biological Process muscle contractionSource:GO_Central1 Publication
Biological Process myofibril assemblySource:GO_Central1 Publication
Biological Process pointed-end actin filament cappingSource:InterPro

Cellular Location

Cytoplasm, cytoskeleton
In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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