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Mouse Anti-TMOD1 Recombinant Antibody (CBYJT-3539) (CBMAB-T2865-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMOD1 (Tropomodulin 1). The antibody can be used for immunoassay techniques, such as WB.
See all TMOD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3539
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TMOD1(NP_003266) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TMOD1 Gene(Protein Coding) Tropomodulin 1
Introduction
TMOD1 is a member of the tropomodulin family. TMOD1 is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton.
Entrez Gene ID
7111
UniProt ID
P28289
Alternative Names
Tropomodulin 1; Erythrocyte Tropomodulin; D9S57E; E-Tmod; TMOD; E-Tropomodulin; Tropomodulin-1; ETMOD
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Biological Process
Biological Process actin filament organizationSource:GO_Central1 Publication
Biological Process adult locomotory behaviorSource:Ensembl
Biological Process lens fiber cell developmentSource:Ensembl
Biological Process muscle contractionSource:GO_Central1 Publication
Biological Process myofibril assemblySource:GO_Central1 Publication
Biological Process pointed-end actin filament cappingSource:InterPro
Cellular Location
Cytoplasm, cytoskeleton
In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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