TNFSF4

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4 Gene(Protein Coding) TNF Superfamily Member 4

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Biological Process acute inflammatory response Source:BHF-UCL
Biological Process cellular response to lipopolysaccharide Source:BHF-UCL1 Publication
Biological Process cellular response to prostaglandin E stimulus Source:BHF-UCL1 Publication
Biological Process defense response to nematode Source:BHF-UCL
Biological Process immune response Source:InterPro
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process memory T cell activation Source:BHF-UCL
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process negative regulation of interferon-gamma production Source:BHF-UCL
Biological Process negative regulation of interleukin-17 production Source:BHF-UCL1 Publication
Biological Process negative regulation of regulatory T cell differentiation Source:BHF-UCL
Biological Process negative regulation of T-helper 1 cell differentiation Source:BHF-UCL
Biological Process positive regulation of alpha-beta T cell proliferation Source:BHF-UCL
Biological Process positive regulation of B cell activation Source:BHF-UCL
Biological Process positive regulation of CD4-positive, alpha-beta T cell costimulation Source:BHF-UCL
Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation Source:BHF-UCL
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of chemokine production Source:BHF-UCL
Biological Process positive regulation of cytokine production Source:GO_Central1 Publication
Biological Process positive regulation of immunoglobulin mediated immune response Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process positive regulation of inflammatory response Source:BHF-UCL1 Publication
Biological Process positive regulation of interferon-gamma production Source:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-10 production Source:BHF-UCL
Biological Process positive regulation of interleukin-12 production Source:BHF-UCL
Biological Process positive regulation of interleukin-13 production Source:BHF-UCL
Biological Process positive regulation of interleukin-4 production Source:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source:BHF-UCL
Biological Process positive regulation of interleukin-6 production Source:BHF-UCL1 Publication
Biological Process positive regulation of memory T cell differentiation Source:BHF-UCL
Biological Process positive regulation of T cell cytokine production Source:BHF-UCL
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T-helper 2 cell differentiation Source:BHF-UCL
Biological Process positive regulation of type 2 immune response Source:BHF-UCL
Biological Process regulation of adaptive immune response Source:BHF-UCL
Biological Process regulation of inflammatory response Source:BHF-UCL
Biological Process response to nitrogen dioxide Source:BHF-UCL
Biological Process response to virus Source:BHF-UCL
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T-helper 2 cell activation Source:BHF-UCL

Membrane

Systemic lupus erythematosus (SLE):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Cytoplasmic: 1-23
Helical: 24-50
Extracellular: 51-183