TPBG

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Full Name
TPBG Gene(Protein Coding) Trophoblast Glycoprotein
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Biological Process
Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process dendrite arborization Source:Ensembl
Biological Process mesenchymal cell migration Source:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process olfactory learning Source:Ensembl
Biological Process positive regulation of chemotaxis Source:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascade Source:Ensembl
Biological Process positive regulation of protein kinase B signaling Source:Ensembl
Biological Process positive regulation of synapse assembly Source:Ensembl
Biological Process protein localization to plasma membrane Source:Ensembl
Biological Process synaptic transmission, GABAergic Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 32-355
Helical: 356-376
Cytoplasmic: 377-420
PTM
Highly glycosylated.
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Anti-TPBG antibodies

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Rabbit Anti-TPBG Recombinant Antibody (
6E9) (V2LY-0725-LY1448)

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Target: TPBG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 6E9
Application*: E, WB, IH
Datasheet SDS

Rabbit Anti-TPBG Recombinant Antibody (
1D4) (V2LY-0725-LY1332)

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Target: TPBG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1D4
Application*: E, IH
Datasheet SDS

Human Anti-TPBG Recombinant Antibody (
13C3) (V2LY-0725-LY906)

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Target: TPBG
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 13C3
Application*: E
Datasheet SDS

TPBG Matched Antibody Pair (1262) (APMAB-1262LY)

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Target: TPBG
Specificity: Human
Datasheet SDS

Rabbit Anti-TPBG Recombinant Antibody (E4T8Q) (CBMAB-CP2831-LY)

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Target: TPBG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E4T8Q
Application*: WB, F
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (3D6) (CBMAB-A9451-LY)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: 3D6
Application*: WB, E
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (1B6) (CBMAB-A9450-LY)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B6
Application*: SE, E
Datasheet SDS

Recombinant Mouse Anti-TPBG Recombinant Antibody (B5C9) (CBMAB-XB1177-YC)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: B5C9
Application*: E, F, IF, FN, WB
Datasheet SDS

Recombinant Mouse Anti-TPBG Recombinant Antibody (B5C12) (CBMAB-XB1176-YC)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: B5C12
Application*: E, F, IF, WB
Datasheet SDS

Recombinant Mouse Anti-TPBG Recombinant Antibody (B3F1) (CBMAB-XB1175-YC)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: B3F1
Application*: E, F, IF, FN, WB
Datasheet SDS

Recombinant Mouse Anti-TPBG Recombinant Antibody (B1C3) (CBMAB-XB1174-YC)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: B1C3
Application*: E, F, FN
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (NDOG1) (CBMAB-T3783-YJ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: NDOG1
Application*: F, C
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBYJT-4301) (CBMAB-T3781-YJ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4301
Application*: SE, E
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBYJT-4300) (CBMAB-T3780-YJ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4300
Application*: E
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBYJT-4299) (CBMAB-T3779-YJ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4299
Application*: WB
Datasheet SDS

Mouse Anti-TPBG (AA 31-355) Recombinant Antibody (CBXO-0294) (CBMAB-O0435-CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0294
Application*: E, F
Datasheet SDS

Mouse Anti-TPBG (AA 219-328) Recombinant Antibody (CBXO-0454) (CBMAB-O0434-CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: CBXO-0454
Application*: E, WB
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (MM0645-7A11) (CBMAB-2116CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: MM0645-7A11
Application*: P, F
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBLQT-003) (CBMAB-2079CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Human
Clone: CBLQT-003
Application*: WB, E, IF, F
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBLQT-002) (CBMAB-2077CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLQT-002
Application*: F
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBLQT-005) (CBMAB-2076CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLQT-005
Application*: F
Datasheet SDS

Mouse Anti-TPBG Recombinant Antibody (CBLQT-001) (CBMAB-2074CQ)

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Target: TPBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLQT-001
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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