TPBG

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

TPBG Gene(Protein Coding) Trophoblast Glycoprotein

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process dendrite arborization Source:Ensembl
Biological Process mesenchymal cell migration Source:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process olfactory learning Source:Ensembl
Biological Process positive regulation of chemotaxis Source:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascade Source:Ensembl
Biological Process positive regulation of protein kinase B signaling Source:Ensembl
Biological Process positive regulation of synapse assembly Source:Ensembl
Biological Process protein localization to plasma membrane Source:Ensembl
Biological Process synaptic transmission, GABAergic Source:Ensembl

Cell membrane

Extracellular: 32-355
Helical: 356-376
Cytoplasmic: 377-420

Highly glycosylated.