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Mouse Anti-TPBG Recombinant Antibody (3D6) (CBMAB-A9451-LY)

The product is antibody recognizes TPBG. The antibody 3D6 immunoassay techniques such as: WB, ELISA.
See all TPBG antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3D6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TPBG (NP_006661, 219 a.a. ~ 328 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TPBG Gene(Protein Coding) Trophoblast Glycoprotein
Entrez Gene ID
Human7162
Rat83684
UniProt ID
HumanQ13641
RatQ5PQV5
Alternative Names
5T4; 5T4-AG; M6P1
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Biological Process
Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process dendrite arborization Source:Ensembl
Biological Process mesenchymal cell migration Source:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process olfactory learning Source:Ensembl
Biological Process positive regulation of chemotaxis Source:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascade Source:Ensembl
Biological Process positive regulation of protein kinase B signaling Source:Ensembl
Biological Process positive regulation of synapse assembly Source:Ensembl
Biological Process protein localization to plasma membrane Source:Ensembl
Biological Process synaptic transmission, GABAergic Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 32-355
Helical: 356-376
Cytoplasmic: 377-420
PTM
Highly glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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