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Mouse Anti-TPBG Recombinant Antibody (CBYJT-4300) (CBMAB-T3780-YJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBYJT-4300
Application
ELISA
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
TPBG Gene(Protein Coding) Trophoblast Glycoprotein
Introduction
TPBG is a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers.
Entrez Gene ID
7162
UniProt ID
Q13641
Alternative Names
Trophoblast Glycoprotein; 5T4 Oncofetal Trophoblast Glycoprotein; Wnt-Activated Inhibitory Factor 1; 5T4 Oncotrophoblast Glycoprotein; 5T4 Oncofetal Antigen; WAIF1; M6P1; 5T4; 5T4AG
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Biological Process
Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process dendrite arborization Source:Ensembl
Biological Process mesenchymal cell migration Source:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process olfactory learning Source:Ensembl
Biological Process positive regulation of chemotaxis Source:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascade Source:Ensembl
Biological Process positive regulation of protein kinase B signaling Source:Ensembl
Biological Process positive regulation of synapse assembly Source:Ensembl
Biological Process protein localization to plasma membrane Source:Ensembl
Biological Process synaptic transmission, GABAergic Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 32-355
Helical: 356-376
Cytoplasmic: 377-420
PTM
Highly glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TPBG Matched Antibody Pair (1262) (CAT#: APMAB-1262LY)

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Recombinant Mouse Anti-TPBG Recombinant Antibody (B5C9) (CAT#: CBMAB-XB1177-YC)

Recombinant Mouse Anti-TPBG Recombinant Antibody (B3F1) (CAT#: CBMAB-XB1175-YC)

Mouse Anti-TPBG Recombinant Antibody (CBLQT-001) (CAT#: CBMAB-2074CQ)

TPBG Matched Antibody Pair (1262) (CAT#: APMAB-1262LY)

Rabbit Anti-TPBG Recombinant Antibody (
6E9) (CAT#: V2LY-0725-LY1448)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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