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TRAF1

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Full Name

TRAF1 Gene(Protein Coding) TNF Receptor Associated Factor 1

Function

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process positive regulation of JNK cascade Source:GO_Central1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:GO_Central1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:GO_Central1 Publication

Cellular Location

cytoplasm
cytoplasmic side of plasma membrane
cytosol

PTM

Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.

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Anti-TRAF1 antibodies

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Rat Anti-TRAF1 Recombinant Antibody (1F3) (CBMAB-CP2841-LY)

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Target: TRAF1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 1F3

Application*: WB, IP, P, IF (IC)

Mouse Anti-TRAF1 Recombinant Antibody (1A6) (CBMAB-A9472-LY)

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Target: TRAF1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A6

Application*: WB, E

Mouse Anti-Traf1 Recombinant Antibody (CBYJT-4491) (CBMAB-T3994-YJ)

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Target: Traf1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYJT-4491

Application*: WB

Rabbit Anti-TRAF1 Recombinant Antibody (CBYJT-4490) (CBMAB-T3993-YJ)

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Target: TRAF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBYJT-4490

Application*: WB, IP, P, IF, F

Mouse Anti-TRAF1 Recombinant Antibody (CBYJT-4489) (CBMAB-T3992-YJ)

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Target: TRAF1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4489

Application*: WB, IP, IF, E

Mouse Anti-TRAF1 Recombinant Antibody (CBYJT-4488) (CBMAB-T3991-YJ)

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Target: TRAF1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4488

Application*: WB, IP, IF, E

Rabbit Anti-TRAF1 Recombinant Antibody (CBYJT-4487) (CBMAB-T3990-YJ)

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Target: TRAF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4487

Application*: F, IC, IF, P, IP, WB

Mouse Anti-TRAF1 Recombinant Antibody (CBYJT-4486) (CBMAB-T3989-YJ)

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Target: TRAF1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4486

Application*: WB

Mouse Anti-TRAF1 Recombinant Antibody (CBYJT-4485) (CBMAB-T3988-YJ)

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Target: TRAF1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-4485

Application*: E, WB

Rat Anti-TRAF1 Recombinant Antibody (CBYJT-4484) (CBMAB-T3987-YJ)

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Target: TRAF1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-4484

Application*: IC, IF, P, WB

TRAF1 Matched Antibody Pair (1265) (APMAB-1265LY)

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Target: TRAF1

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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