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Mouse Anti-TRAF1 Recombinant Antibody (CBYJT-4486) (CBMAB-T3989-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAF1 (TNF Receptor Associated Factor 1). The antibody can be used for immunoassay techniques, such as WB.
See all TRAF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4486
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Partial human TRAF1 recombinant protein (1-182 a.a.) expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-182

Target

Full Name
TRAF1 Gene(Protein Coding) TNF Receptor Associated Factor 1
Introduction
TRAF1 is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. TRAF1 and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. It complex formed by TRAF1 and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of TRAF1 can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.
Entrez Gene ID
7185
UniProt ID
Q13077
Alternative Names
TNF Receptor Associated Factor 1; EBI6; Epstein-Barr Virus-Induced Protein 6; Epstein-Bar Virus-Induced Protein 6; TNF Receptor-Associated Factor 1; MGC:10353
Function
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process positive regulation of JNK cascade Source:GO_Central1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:GO_Central1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:GO_Central1 Publication
Cellular Location
cytoplasm
cytoplasmic side of plasma membrane
cytosol
PTM
Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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