TRAP1

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Full Name
TRAP1
Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Biological Process
Biological Process chaperone-mediated protein folding Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of cellular respiration Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source:ParkinsonsUK-UCLBy Similarity
Biological Process negative regulation of reactive oxygen species biosynthetic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein folding Source:GO_Central1 Publication
Biological Process translational attenuation Source:CACAO1 Publication
Cellular Location
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
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Anti-TRAP1 antibodies

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Rabbit Anti-TRAP1 Recombinant Antibody (D3D7N) (CBMAB-CP1076-LY)

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Target: TRAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D3D7N
Application*: WB, IP, IF (IC)
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (3H4-2H6) (CBMAB-T4067-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3H4-2H6
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (9B6) (CBMAB-T4066-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Mouse
Clone: 9B6
Application*: WB
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4554) (CBMAB-T4065-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBYJT-4554
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4553) (CBMAB-T4064-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: CBYJT-4553
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4552) (CBMAB-T4063-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4552
Application*: IB, IC, IF
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4551) (CBMAB-T4062-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4551
Application*: IB
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (Trap1-6) (CBMAB-T4061-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: Trap1-6
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4550) (CBMAB-T4060-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4550
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4549) (CBMAB-T4059-YJ)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4549
Application*: IF, IP, WB
Datasheet SDS

Rabbit Anti-TRAP1 Recombinant Antibody (CBYJT-4548) (CBMAB-T4058-YJ)

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Target: TRAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4548
Application*: WB, P, IC
Datasheet SDS

Mouse Anti-TRAP1 Recombinant Antibody (CBFYH-2808) (CBMAB-H3872-FY)

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Target: TRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: CBFYH-2808
Application*: WB, P, F, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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