Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4552) (CBMAB-T4063-YJ)

Name: Mouse Anti-TRAP1 Recombinant Antibody (CBYJT-4552)
SKU: CBMAB-T4063-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4552

Application

IB, ICC, IF

Immunogen

This antibody recognizes human TRAP1. Other species have not been investigated

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRAP1

Introduction

TRAP1 is a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. TRAP1 has ATPase activity and interacts with tumor necrosis factor type I. TRAP1 may function in regulating cellular stress responses.

Entrez Gene ID

10131

UniProt ID

Q12931

Alternative Names

TNF Receptor Associated Protein 1; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; TNFR-Associated Protein 1; TRAP-1; HSP 75; HSP75

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Biological Process

Biological Process chaperone-mediated protein folding Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of cellular respiration Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source:ParkinsonsUK-UCLBy Similarity
Biological Process negative regulation of reactive oxygen species biosynthetic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein folding Source:GO_Central1 Publication
Biological Process translational attenuation Source:CACAO1 Publication

Cellular Location

Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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