TRIM25

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

Full Name

TRIM25 Gene(Protein Coding) Tripartite Motif Containing 25

Function

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599).
Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980).
Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712).
Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849).
Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755).
Mediates estrogen action in various target organs (PubMed:22452784).
Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity).

Biological Process

Biological Process cellular response to leukemia inhibitory factor Source:Ensembl
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of viral entry into host cell Source:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein monoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process regulation of protein localization Source:UniProtKB
Biological Process regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process response to estrogen Source:UniProtKB1 Publication
Biological Process response to vitamin D Source:Ensembl
Biological Process suppression of viral release by host Source:Ensembl
Biological Process ubiquitin-dependent ERAD pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process viral release from host cell Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cytoplasm, Stress granule
Nucleus

PTM

Auto-ISGylated.