TRIM33

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Full Name
TRIM33 Gene(Protein Coding) Tripartite Motif Containing 33
Function
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Cellular Location
Nucleus
In discrete nuclear dots resembling nuclear bodies.
Involvement in disease
A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
PTM
Sumoylated with SUMO1.
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Anti-TRIM33 antibodies

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Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4752) (CBMAB-T4292-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4752
Application*: E, WB, IC
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (
12E7) (V2LY-0725-LY424)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Pig, Mouse, Rat
Clone: 12E7
Application*: E, WB, IC
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBT1207) (V2LY-0625-LY2943)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBT1207
Application*: WB, IF, IC
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CB436A) (CBMAB-CA436LY)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Pig, Mouse, Rat
Clone: CB436A
Application*: ELISA, WB, ICC
Datasheet SDS

Recombinant Mouse Anti-TRIM33 Antibody (CBAb232) (CBMAB-Ab232-LY)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb232
Application*: WB
Datasheet SDS

Rabbit Anti-TRIM33 Recombinant Antibody (D7U4F) (CBMAB-CP2865-LY)

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Target: TRIM33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7U4F
Application*: WB, IP, P, F, CI
Datasheet SDS

Rabbit Anti-TRIM33 Recombinant Antibody (E1N2Z) (CBMAB-CP2864-LY)

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Target: TRIM33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Cattle, Dog, Horse
Clone: E1N2Z
Application*: WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (6F4) (CBMAB-A9515-LY)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6F4
Application*: WB, E
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (6D1) (CBMAB-A9514-LY)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 6D1
Application*: WB, E
Datasheet SDS

Rabbit Anti-TRIM33 Recombinant Antibody (CBYJT-4756) (CBMAB-T4297-YJ)

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Target: TRIM33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Cattle, Dog, Horse
Clone: CBYJT-4756
Application*: WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4755) (CBMAB-T4296-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-4755
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4754) (CBMAB-T4294-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4754
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4753) (CBMAB-T4293-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4753
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4751) (CBMAB-T4291-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4751
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4750) (CBMAB-T4290-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4750
Application*: WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4749) (CBMAB-T4289-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4749
Application*: WB
Datasheet SDS

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4748) (CBMAB-T4288-YJ)

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Target: TRIM33
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4748
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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