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Recombinant Mouse Anti-TRIM33 Antibody (CBAb232) (CBMAB-Ab232-LY)

The product is antibody recognizes TRIM33. The antibody CBAb232 immunoassay techniques such as: WB 1:500-1:2000.
See all TRIM33 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBAb232
Antibody Isotype
IgG
Application
WB 1:500-1:2000

Basic Information

Immunogen
Recombinant protein of human TRIM33
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRIM33 Gene(Protein Coding) Tripartite Motif Containing 33
Introduction
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.
Entrez Gene ID
UniProt ID
Alternative Names
TRIM33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA; tripartite motif containing 33
Function
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Cellular Location
Nucleus
In discrete nuclear dots resembling nuclear bodies.
Involvement in disease
A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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