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Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4750) (CBMAB-T4290-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM33 (Tripartite Motif Containing 33). The antibody can be used for immunoassay techniques, such as WB.
See all TRIM33 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4750
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
This antibody detects endogenous levels TRIM33 and does not cross-react with related proteins
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
100 mM Tris-glycine, 150 mM NaCl, pH 7.4, 50% Glycerol
Preservative
0.2% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRIM33 Gene(Protein Coding) Tripartite Motif Containing 33
Introduction
TRIM33 is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. It is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Entrez Gene ID
51592
UniProt ID
Q9UPN9
Alternative Names
Tripartite Motif Containing 33; Transcriptional Intermediary Factor 1 Gamma; RING-Type E3 Ubiquitin Transferase TRIM33; RET-Fused Gene 7 Protein; Ectodermin Homolog; Protein Rfg7; TIF1-Gamma; TIF1G; RFG7; Transcription Intermediary Factor 1-Gamma; Tripartite Motif-Containing Protein 33; E3 Ubiquitin-Protein Ligase TRIM33
Function
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Cellular Location
Nucleus
In discrete nuclear dots resembling nuclear bodies.
Involvement in disease
A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

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