Rabbit Anti-TRIM33 Recombinant Antibody (E1N2Z) (CBMAB-CP2864-LY)

Name: Rabbit Anti-TRIM33 Recombinant Antibody (E1N2Z)
SKU: CBMAB-CP2864-LY
Rating: 5 (1 reviews)

See all TRIM33 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

E1N2Z

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRIM33 protein.

Specificity

Human, Cattle, Dog, Horse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TRIM33 Gene(Protein Coding) Tripartite Motif Containing 33

Introduction

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	51592
Cattle	533296
Horse	100065226
Dog	475804

UniProt ID

Human	Q9UPN9
Cattle	F1MNE1
Horse	F6XJ99
Dog	A0A8I3PQG1

Alternative Names

Tripartite Motif Containing 33; Transcriptional Intermediary Factor 1 Gamma; RING-Type E3 Ubiquitin Transferase TRIM33; RET-Fused Gene 7 Protein; Ectodermin Homolog; Protein Rfg7; TIF1-Gamma; TIF1G; RFG7; Transcription Intermediary Factor 1-Gamma; Tripartite Motif-Containing Protein 33; E3 Ubiquitin-Protein Ligase TRIM33;

Function

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Biological Process

Biological Process negative regulation of BMP signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication

Cellular Location

Nucleus
In discrete nuclear dots resembling nuclear bodies.

Involvement in disease

A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.

PTM

Sumoylated with SUMO1.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-TRIM33 Recombinant Antibody (E1N2Z)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TRIM33 Recombinant Antibody (CBT1207) (CAT#: V2LY-0625-LY2943)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4755) (CAT#: CBMAB-T4296-YJ)

Mouse Anti-TRIM33 Recombinant Antibody (6D1) (CAT#: CBMAB-A9514-LY)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4751) (CAT#: CBMAB-T4291-YJ)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4753) (CAT#: CBMAB-T4293-YJ)

Mouse Anti-TRIM33 Recombinant Antibody (
12E7) (CAT#: V2LY-0725-LY424)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4752) (CAT#: CBMAB-T4292-YJ)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4754) (CAT#: CBMAB-T4294-YJ)

Mouse Anti-TRIM33 Recombinant Antibody (CB436A) (CAT#: CBMAB-CA436LY)

Mouse Anti-TRIM33 Recombinant Antibody (CBYJT-4750) (CAT#: CBMAB-T4290-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry