TRIM9
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq]
Full Name
tripartite motif-containing 9
Function
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cell projection, dendrite
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Synapse
Cytoplasm, cytoskeleton
Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity).
Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810).
Cell projection, dendrite
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Synapse
Cytoplasm, cytoskeleton
Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity).
Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810).
PTM
Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro.
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Anti-TRIM9 antibodies
+ Filters
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F12
Application*: WB, E
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5180
Application*: WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4823
Application*: F, IF, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4647
Application*: F, IF
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4509
Application*: WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4501
Application*: F, IF, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4398
Application*: IF, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4326
Application*: F, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4151
Application*: F, IF, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4060
Application*: F, IF, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4367
Application*: F, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-4846
Application*: WB, IP, IF, E
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-4845
Application*: WB, IP, IF, E
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: CBYJT-4844
Application*: WB, F, IC, IF
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4843
Application*: WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4842
Application*: WB, IF, F
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4841
Application*: IF, F
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4840
Application*: WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4839
Application*: WB, IF
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4838
Application*: WB, F
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4837
Application*: WB, F
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4836
Application*: WB, IF, F
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4835
Application*: E, WB
Target: TRIM9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4834
Application*: WB, IF, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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